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Article

The mitotic checkpoint regulator RAE1 induces aggressive breast cancer cell phenotypes by mediating epithelial-mesenchymal transition.

Scientific reports - 9 Feb 2017

Oh Ji Hoon, Hur Ho, Lee Ji-Yeon, Kim Yeejeong, Seo Younsoo, Kim Myoung Hee

Abstract excerpt

The gene RAE1 encodes ribonucleic acid export 1 (RAE1), which is involved in mRNA export and is known to serve as a mitotic checkpoint regulator. In addition, RAE1 haplo-insufficiency leads to chromosome missegregation and early aging-associated phenotypes. In humans, a positive correlation has been found between RAE1 copy number abnormalities and gene amplification in breast cancer cells. However, the precise...

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Source

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Identifiers

PMID: 28181567
DOI: 10.1038/srep42256
PMCID: PMC5299842

Genes

RAE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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