Article
Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype.
Nature communications - 28 Oct 2014
Morrison Vicky Louise, James Martyn John, Grzes Katarzyna, Cook Peter, Glass David Gavin, Savinko Terhi, Lek Hwee San, Gawden-Bone Christian, Watts Colin, Millington Owain Richard, MacDonald Andrew Scott, Fagerholm Susanna Carola
Abstract excerpt
The actin cytoskeleton has been reported to restrict signalling in resting immune cells. Beta2-integrins, which mediate adhesion and cytoskeletal organization, are emerging as negative regulators of myeloid cell-mediated immune responses, but the molecular mechanisms involved are poorly understood. Here, we show that loss of the interaction between beta2-integrins and kindlin-3 abolishes the actin-linkage of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.