Article
Emergence and evolution of chimeric pseudogenes (φgenes) contribute to genetic and functional diversity of the human genome.
Nucleic acids research - 23 Apr 2026
Jadhav Amruta R, Sahoo Sushmita, Kuber Yash L, Hatwar Krutika, Varanwal Avinash, Tanwar Khushi, Palwankar Shubhankar, Chatrasal Gauri, Mali Avinash M, Bapat Sharmila A
Abstract excerpt
Genome evolution through rearrangements and selection drives the emergence of new genes, gene families, and species. Although pseudogenes (φgenes) are often regarded as "dead on arrival" due to disruptive mutations or loss of regulatory elements, our earlier work revealed that several φgenes remain transcriptionally active, challenging this assumption. Here, we show that segmental duplications at proximal loci...
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