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Article

NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification

14 Nov 2018

Abstract excerpt

BACKGROUND: Inflammation helps regulate normal growth and tissue repair. Although bone morphogenetic proteins (BMPs) and inflammation are known contributors to abnormal bone formation, how these pathways interact in ossification remains unclear. METHODS: We examined this potential link in patients with fibrodysplasia ossificans progressiva (FOP), a genetic condition of progressive heterotopic ossification caused...

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PMID: 30429363
DOI: 10.1172/jci.insight.122958

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