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Article

Depletion of Mast Cells and Macrophages Impairs Heterotopic Ossification in an Acvr1R206H Mouse Model of Fibrodysplasia Ossificans Progressiva.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2018

Convente Michael R, Chakkalakal Salin A, Yang EnJun, Caron Robert J, Zhang Deyu, Kambayashi Taku, Kaplan Frederick S, Shore Eileen M

Abstract excerpt

Heterotopic ossification (HO) is a clinical condition that often reduces mobility and diminishes quality of life for affected individuals. The most severe form of progressive HO occurs in those with fibrodysplasia ossificans progressiva (FOP; OMIM #135100), a genetic disorder caused by a recurrent heterozygous gain-of-function mutation (R206H) in the bone morphogenetic protein (BMP) type I receptor ACVR1/ALK2. In...

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Activin Receptors, Type I
Bone Morphogenetic Proteins
Cell Count
Inflammation Mediators

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myositis Ossificans

Ossification, Heterotopic

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Open in PubMed Open full text

Identifiers

PMID: 28986986
DOI: 10.1002/jbmr.3304
PMCID: PMC7737844

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Depletion of Mast Cells and Macrophages Impairs Heterotopic Ossification in an Acvr1R206H Mouse Model of Fibrodysplasia Ossificans Progressiva.PMID 28986986Read ↗

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