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Article

Transcriptomic Differences Underlying the Activin-A Induced Large Osteoclast Formation in Both Healthy Control and Fibrodysplasia Ossificans Progressiva Osteoclasts.

International journal of molecular sciences - 6 Apr 2023

Schoenmaker Ton, Zwaak Joy, Loos Bruno G, Volckmann Richard, Koster Jan, Eekhoff E Marelise W, de Vries Teun J

Abstract excerpt

Fibrodysplasia Ossificans Progressiva (FOP) is a very rare genetic disease characterized by progressive heterotopic ossification (HO) of soft tissues, leading to immobility and premature death. FOP is caused by a mutation in the Activin receptor Type 1 (ACVR1) gene, resulting in altered responsiveness to Activin-A. We recently revealed that Activin-A induces fewer, but larger and more active, osteoclasts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37047804
DOI: 10.3390/ijms24076822
PMCID: PMC10095588

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