Article

Integrated Whole Genome and Transcriptome Sequencing as a Framework for Pediatric and Adolescent AML Diagnosis and Risk Assessment

2025-01-22

Abstract excerpt

<title>Abstract</title> <p>Pediatric acute myeloid leukemia (AML) exhibits distinct genetic characteristics, including unique driver alterations and mutations with prognostic and therapeutic significance. Emerging rare, recurrent genetic abnormalities and their associations with outcomes emphasize the need for high-throughput molecular diagnostic tools. Whole genome sequencing (WGS) reliably detects key AML bioma...

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Literature Corpus work: 7207c753-384b-5682-aa33-0357aa38177c
DOI: 10.21203/rs.3.rs-5775959/v1

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