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Article

ACSL4 knockdown inhibits colorectal cancer progression through stimulating anti-tumor immunity

11 Jun 2025

Abstract excerpt

BACKGROUND: Long-chain acyl-CoA synthetase 4 (ACSL4), a crucial modulator of ferroptosis, is associated with tumor progression, though its impact on colorectal cancer (CRC) immune dynamics is not fully understood. METHODS: ACSL4 expression was analyzed in CRC tissues and correlated with patient prognosis. Effects of ACSL4 were evaluated in CRC cells in vitro and in subcutaneous and orthotopic CRC models. Flow...

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PMID: 40505269
DOI: 10.1016/j.neo.2025.101194

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