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Article

The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region.

Scientific reports - 7 Apr 2017

Tapken Daniel, Steffensen Thomas Bielefeldt, Leth Rasmus, Kristensen Lise Baadsgaard, Gerbola Alexander, Gajhede Michael, Jørgensen Flemming Steen, Olsen Lars, Kastrup Jette Sandholm

Abstract excerpt

Ionotropic glutamate receptors (iGluRs) are responsible for most of the fast excitatory communication between neurons in our brain. The GluD2 receptor is a puzzling member of the iGluR family: It is involved in synaptic plasticity, plays a role in human diseases, e.g. ataxia, binds glycine and D-serine with low affinity, yet no ligand has been discovered so far that can activate its ion channel. In this study, we...

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Identifiers

PMID: 28387240
DOI: 10.1038/srep46145
PMCID: PMC5384001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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