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Article

Mutation of valine 53 at the interface between extracellular and transmembrane domains of the β2 principal subunit affects the GABAA receptor gating.

European journal of pharmacology - 15 May 2023

Kłopotowski Karol, Michałowski Michał A, Gos Michalina, Mosiądz Daniela, Czyżewska Marta M, Mozrzymas Jerzy W

Abstract excerpt

GABAA receptors (gamma-aminobutyric acid type A receptors) are pentameric ligand-gated ion channels mediating inhibition in adult mammalian brains. Their static structure has been intensely studied in the past years but the underlying molecular activatory mechanisms remain obscure. The interface between extracellular and transmembrane domains has been recognized as a key player in the receptor gating. However,...

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PMID: 36934960
DOI: 10.1016/j.ejphar.2023.175664

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