Article

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated disease

2023-06-24

Abstract excerpt

Understanding the mechanisms that drive TDP-43 pathology is integral to combating neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). To address this, we sought to determine the timeline of proteomic alterations across disease course in TDP-43 proteinopathy. Using longitudinal quantitative proteomics analysis of cortex samples from the cytoplasmic TD...

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Literature Corpus work: 4b9ceda9-277b-5ea1-b767-24ac502c9acf
DOI: 10.1101/2023.06.21.546009

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