Article

Disrupted Brain Hierarchical Organization in Alzheimer′s Disease Progression

2025-12-12

Abstract excerpt

Alzheimer′s disease (AD) arises from synergistic interactions between amyloid–β, tau, and neurodegeneration, yet it remains unclear how these mechanisms reshape the hierarchical organization of large-scale brain dynamics. Here, we quantified directed causal interactions across 134 participants spanning the AD continuum, comprising 46 amyloid–negative healthy controls (HC−), 36 amyloid–positive healthy controls (HC...

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Literature Corpus work: 042b8d0c-7220-5b9f-b86b-ce2ff17cc3f5
DOI: 10.64898/2025.12.11.25342039

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