Article

NAD modulates DNA methylation and cell differentiation

2020-08-02

Abstract excerpt

Nutritional intake impacts the human epigenome by directing epigenetic pathways in normal cell development via as yet unknown molecular mechanisms. Consequently, imbalance in the nutritional intake is able to dysregulate the epigenetic profile and drive cells towards malignant transformation. Herein, we present a novel epigenetic effect of the essential nutrient, NAD. We demonstrate that impairment of DNMT1 enzyma...

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Literature Corpus work: 71cc8d58-6623-54a2-862d-2d9bc9b87ce7
DOI: 10.1101/2020.07.31.231555

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