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Article

NAD+ Metabolism in Aging and Cancer

2018-11-09

Abstract excerpt

Aging is a major risk factor for many types of cancer, and the molecular mechanisms implicated in aging, progeria syndromes, and cancer pathogenesis display considerable similarities. Maintaining redox homeostasis, efficient signal transduction, and mitochondrial metabolism is essential for genome integrity and for preventing progression to cellular senescence or tumorigenesis. NAD+ is a central signaling molecule...

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Literature Corpus work
245078b2-1cf2-5000-9418-a7f53794eb25
DOI
10.1146/annurev-cancerbio-030518-055905
Open publication

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NAD+ Metabolism in Aging and CancerDOI 10.1146/annurev-cancerbio-030518-055905
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