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Article

Long-Read Sequencing Enhances Pharmacogenomic Profiling by Resolving Complex Haplotypes, Novel Star Alleles, and Structural Variants.

Clinical pharmacology and therapeutics - 1 Feb 2026

Samarasinghe Sumudu Rangika, Gaedigk Andrea, Swen Jesse J, Guchelaar Henk-Jan, Nagaraj Shivashankar H

Abstract excerpt

Pharmacogenomics has shifted drug therapy from trial-and-error to personalized approaches by leveraging genetic biomarkers. However, traditional genotyping assays and short-read sequencing often fail to resolve structural complexity in pharmacogenes, leading to ambiguous haplotypes and incorrect phenotype predictions. To evaluate the potential of emerging long-read sequencing technologies in overcoming these...

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Source

Identifiers

PMID: 41311006
DOI: 10.1002/cpt.70115

Genes

CYP2B6
CYP2C19
CYP2C9
CYP4F2
SLCO1B1
UGT1A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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