Article

Activating <i>RET</i> Mutations Promotes Osteoblastic Bone Metastases in Medullary Thyroid Cancer

2025-07-14

Abstract excerpt

<h4>Summary</h4> Development of bone metastases increases mortality in patients with medullary thyroid cancer (MTC), with ∼50% survival at 5 years after diagnosis, but the underlying mechanisms are unknown. We show that patient-derived MTC cells ( RET C634W mutant TT cells and RET M918T mutant MZCRC1 cells) promote an osteoblastic phenotype due to reduced bone resorption. Mechanistically, activated RET increase...

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Literature Corpus work: 71a1ffb0-3c44-5543-9d70-63ba7cd75715
DOI: 10.1101/2025.07.09.663851

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