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Article

CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis

17 Mar 2012

Abstract excerpt

The CCN family of proteins is composed of six secreted proteins (CCN1-6), which are grouped together based on their structural similarity. These matricellular proteins are involved in a large spectrum of biological processes, ranging from development to disease. In this review, we focus on CCN3, a founding member of this family, and its role in regulating cells within the bone microenvironment. CCN3 impairs...

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PMID: 22427255
DOI: 10.1007/s12079-012-0161-7

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