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Long noncoding RNA Malat1 inhibits Tead3-Nfatc1–mediated osteoclastogenesis to suppress osteoporosis and bone metastasis

2023-03-20

Abstract excerpt

<title>Abstract</title> <p>MALAT1, one of the few highly conserved nuclear long noncoding RNAs (lncRNAs), is abundantly expressed in normal tissues. Previously, targeted inactivation and genetic rescue experiments identified MALAT1 as a suppressor of breast cancer lung metastasis. On the other hand, Malat1-knockout mice are viable and develop normally. On a quest to discover new roles of MALAT1 in physiological a...

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Literature Corpus work
e17aea44-4c58-5936-ab31-5a8306a7be09
DOI
10.21203/rs.3.rs-2405644/v1
Open publication

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Long noncoding RNA Malat1 inhibits Tead3-Nfatc1–mediated osteoclastogenesis to suppress osteoporosis and bone metastasisDOI 10.21203/rs.3.rs-2405644/v1
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