Article

BRCA Mutations: The Achilles Heel of Breast, Ovarian and Other Epithelial Cancers

2023-02-13

Abstract excerpt

Two related tumor suppressor genes, Brca1 and Brca2, attract a lot of attention from both fundamental and clinical points of view. Oncogenic hereditary mutations in these genes are firmly linked to the early onset of breast and ovarian cancers. However, the molecular mechanisms that drive extensive mutagenesis in these genes are not known. In this review we hypothesize that one of the potential mechanisms behind t...

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Literature Corpus work: 718b6668-aa10-553c-bd42-54b58a20413e
DOI: 10.20944/preprints202302.0205.v1

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