Article
BRCA1 and BRCA2 and the genetics of breast and ovarian cancer.
Human molecular genetics - 1 Apr 2001
Welcsh P L, King M C
Abstract excerpt
Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose individuals to breast and ovarian cancers. Progress in determining the function of BRCA1 and BRCA2 suggests that they are involved in two fundamental cellular processes: DNA damage repair and transcriptional regulation. We evaluate current knowledge of BRCA1 and BRCA2 functions to explain why mutations in BRCA1 and BRCA2 lead specifically...
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