Article
BRCA Mutations-The Achilles Heel of Breast, Ovarian and Other Epithelial Cancers.
International journal of molecular sciences - 5 Mar 2023
Loboda Anna P, Adonin Leonid S, Zvereva Svetlana D, Guschin Dmitri Y, Korneenko Tatyana V, Telegina Alexandra V, Kondratieva Olga K, Frolova Sofia E, Pestov Nikolay B, Barlev Nick A
Abstract excerpt
Two related tumor suppressor genes, BRCA1 and BRCA2, attract a lot of attention from both fundamental and clinical points of view. Oncogenic hereditary mutations in these genes are firmly linked to the early onset of breast and ovarian cancers. However, the molecular mechanisms that drive extensive mutagenesis in these genes are not known. In this review, we hypothesize that one of the potential mechanisms behind...
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