An overview of cancer genetics with focus on involvement of BRCA1/2 genes in breast carcinomas.

doi:10.5455/JPMA.20351

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Article

An overview of cancer genetics with focus on involvement of BRCA1/2 genes in breast carcinomas.

JPMA. The Journal of the Pakistan Medical Association - 1 Jul 2020

Tahir Durr-E-Samin, Rehman Muhammad Saifur, Rehman MuhammadShahnawaz Ul

Abstract excerpt

Cancer is a kind of disease which can be explained at the molecular level as triggered by accretion of damaged deoxyribonucleic acid. There are several genes involved in cancer, mainly belonging to two classes called tumour suppressors and oncogenes. Other than the well-known breast cancer susceptibility 1/2 genes, there are several other genes involved in the development of breast and ovarian cancers. However,...

Topics

BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Female
Genes, BRCA1
Genetic Predisposition to Disease
Humans
Mutation
Ovarian Neoplasms

Source

Open in PubMed

Identifiers

PMID: 32799280
DOI: 10.5455/JPMA.20351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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