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Article

The relevance of salt bridges for the stability of the influenza virus hemagglutinin.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2007

Rachakonda P Sivaramakrishna, Veit Michael, Korte Thomas, Ludwig Kai, Böttcher Christoph, Huang Qiang, Schmidt Michael F G, Herrmann Andreas

Abstract excerpt

Hemagglutinin (HA) of influenza virus undergoes an irreversible conformational change at acidic pH, mediating viral fusion with the host endosomal membrane. To unravel the molecular basis of the pH-dependent stability of HA, we demonstrate by mutagenesis of the prototype HA of virus strain X31 (H3 subtype) that salt bridges, especially a tetrad salt bridge within the monomers, are crucial for folding and...

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Identifiers

PMID: 17218542
DOI: 10.1096/fj.06-7052hyp

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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