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Article

Influenza hemagglutinin (HA) stem region mutations that stabilize or destabilize the structure of multiple HA subtypes.

Journal of virology - 1 Apr 2015

Byrd-Leotis Lauren, Galloway Summer E, Agbogu Evangeline, Steinhauer David A

Abstract excerpt

UNLABELLED: Influenza A viruses enter host cells through endosomes, where acidification induces irreversible conformational changes of the viral hemagglutinin (HA) that drive the membrane fusion process. The prefusion conformation of the HA is metastable, and the pH of fusion can vary significantly among HA strains and subtypes. Furthermore, an accumulating body of evidence implicates HA stability properties as...

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Chlorocebus aethiops
Hemagglutinins
Hydrogen-Ion Concentration
Immunoprecipitation
Influenza A virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Stability

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PMID: 25653452
DOI: 10.1128/JVI.00057-15
PMCID: PMC4442347

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