Article

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT

2025-04-01

Abstract excerpt

Cells generate purine nucleotides through both de novo purine biosynthesis (DNPB) and purine salvage. Purine accumulation represses energetically costly DNPB through feedback inhibition of the enzymatic steps that produce the precursor phosphoribosylamine. Excessive DNPB is associated with human diseases including neurological dysfunction and hyperuricemia. However, the mechanisms explaining how cells balance DNPB...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 718a9844-a230-5181-b593-7e568934d526
DOI: 10.1101/2025.03.29.646096

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPATDOI 10.1101/2025.03.29.646096Read

Role of NUDIX Hydrolases in NAD and ADP-Ribose Metabolism in MammalsSemantic proximity Read

Inosine Triphosphate Pyrophosphatase (ITPase): Functions, Mutations, Polymorphisms and Its Impact on Cancer Therapies.Semantic proximity Read

SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammationSemantic proximity Read

Metabolic constraint of human telomere length by nucleotide salvage efficiencySemantic proximity Read

CRISPR-Cas9 induced mutations along de novo purine synthesis in HeLa cells result in accumulation of individual enzyme substrates and affect purinosome formation.Semantic proximity Read

AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder.Semantic proximity Read

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications.Semantic proximity Read

Defective Nucleotide Catabolism Defines a Subset of Cancers Sensitive to Purine Nucleoside Phosphorylase InhibitionSemantic proximity Read

Reticular Dysgenesis-associated Adenylate Kinase 2 deficiency causes failure of myelopoiesis through disordered purine metabolismSemantic proximity Read

Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma bruceiSemantic proximity Read

Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies.Semantic proximity Read

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome.Semantic proximity Read