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Metabolic constraint of human telomere length by nucleotide salvage efficiency

27 Mar 2025

Abstract excerpt

Human telomere length is tightly regulated and associated with diseases at either extreme, but how these bounds are established remains incompletely understood. Here, we developed a rapid cell-based telomere synthesis assay and found that nucleoside salvage bidirectionally constrains human telomere length. Metabolism of deoxyguanosine (dG) or guanosine via purine nucleoside phosphorylase (PNP) and...

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PMID: 40148339
DOI: 10.1038/s41467-025-58221-7

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