Article

Examination of gene loss in the DNA mismatch repair pathway and its mutational consequences in a fungal phylum

2021-04-14

Abstract excerpt

The DNA mismatch repair (MMR) pathway corrects mismatched bases produced during DNA replication and is highly conserved across the tree of life, reflecting its fundamental importance for genome integrity. Loss of function in one or a few MMR genes can lead to increased mutation rates and microsatellite instability, as seen in some human cancers. While loss of MMR genes has been documented in the context of human d...

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Literature Corpus work: 2aa81a8e-01cd-5d96-b2cc-22823157649a
DOI: 10.1101/2021.04.13.439724

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