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Examination of Gene Loss in the DNA Mismatch Repair Pathway and Its Mutational Consequences in a Fungal Phylum.

Genome biology and evolution - 1 Oct 2021

Phillips Megan A, Steenwyk Jacob L, Shen Xing-Xing, Rokas Antonis

Abstract excerpt

The DNA mismatch repair (MMR) pathway corrects mismatched bases produced during DNA replication and is highly conserved across the tree of life, reflecting its fundamental importance for genome integrity. Loss of function in one or a few MMR genes can lead to increased mutation rates and microsatellite instability, as seen in some human cancers. Although loss of MMR genes has been documented in the context of...

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Identifiers

PMID: 34554246
DOI: 10.1093/gbe/evab219
PMCID: PMC8597960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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