Article
Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance.
Nature communications - 29 Mar 2016
Healey Kelley R, Zhao Yanan, Perez Winder B, Lockhart Shawn R, Sobel Jack D, Farmakiotis Dimitrios, Kontoyiannis Dimitrios P, Sanglard Dominique, Taj-Aldeen Saad J, Alexander Barbara D, Jimenez-Ortigosa Cristina, Shor Erika, Perlin David S
Abstract excerpt
The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles and/or echinocandins. Thus far, cellular mechanisms promoting the emergence of resistance to multiple drug classes have not been described in this organism. Here we demonstrate that a mutator phenotype caused by a mismatch repair defect is prevalent in C....
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