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Article

Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance.

Nature communications - 16 Dec 2024

Bottery Michael J, van Rhijn Norman, Chown Harry, Rhodes Johanna L, Celia-Sanchez Brandi N, Brewer Marin T, Momany Michelle, Fisher Matthew C, Knight Christopher G, Bromley Michael J

Abstract excerpt

The environmental use of azole fungicides has led to selective sweeps across multiple loci in the Aspergillus fumigatus genome causing the rapid global expansion of a genetically distinct cluster of resistant genotypes. Isolates within this cluster are also more likely to be resistant to agricultural antifungals with unrelated modes of action. Here we show that this cluster is not only multi-azole resistant but...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39681549
DOI: 10.1038/s41467-024-54568-5
PMCID: PMC11649685

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