Article
Distinct functions for netrin 1 in chicken and murine semicircular canal morphogenesis.
Development (Cambridge, England) - 15 Sept 2017
Nishitani Allison M, Ohta Sho, Yung Andrea R, Del Rio Tony, Gordon Michael I, Abraira Victoria E, Avilés Evelyn C, Schoenwolf Gary C, Fekete Donna M, Goodrich Lisa V
Abstract excerpt
The vestibular system of the inner ear detects head position using three orthogonally oriented semicircular canals; even slight changes in their shape and orientation can cause debilitating behavioral defects. During development, the canals are sculpted from pouches that protrude from the otic vesicle, the embryonic anlage of the inner ear. In the center of each pouch, a fusion plate forms where cells lose their...
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