Article

Senescent fibroblasts interfere with the tumor immune response in humanized models by inducing neutrophil extracellular traps

2026-02-11

Abstract excerpt

<h4>ABSTRACT</h4> Neutrophils are known to promote tumor progression and metastasis, in part through the release of extracellular traps (NETs), a phenomenon associated with poor prognosis in patients. Here, we demonstrate that senescent fibroblasts, via their senescence-associated secretory phenotype (SASP), promote the recruitment of CD33 + myeloid cells and impair the tumor immune response in an orthotopic hum...

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Literature Corpus work: 712d41cb-fe8e-5dfe-91ba-ade845e2a7c8
DOI: 10.64898/2026.02.09.704891

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