Article
A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.
PloS one - 12 Feb 2010
Coppé Jean-Philippe, Patil Christopher K, Rodier Francis, Krtolica Ana, Beauséjour Christian M, Parrinello Simona, Hodgson J Graeme, Chin Koei, Desprez Pierre-Yves, Campisi Judith
Abstract excerpt
Cellular senescence irreversibly arrests cell proliferation in response to oncogenic stimuli. Human cells develop a senescence-associated secretory phenotype (SASP), which increases the secretion of cytokines and other factors that alter the behavior of neighboring cells. We show here that "senes...
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