Article

Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells

2025-02-25

Abstract excerpt

Mammalian inner ear sensory hair cells are highly sensitive to environmental stress and do not regenerate, making hearing loss progressive and permanent. The paucity and extreme inaccessibility of these cells hinder the development of regenerative and otoprotective strategies, Direct lineage reprogramming to generate large quantities of hair cell-like cells in vitro offers a promising approach to overcome these ex...

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Literature Corpus work: f9baaef3-085a-572c-9659-aabb2be4f271
DOI: 10.1101/2025.02.20.639352

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