Article

Impaired erythroid maturation in murine embryos upon loss of the preeclampsia-associated serine protease prostasin

2024-10-25

Abstract excerpt

In humans, the membrane-bound serine protease prostasin encoded by Prss8 is associated with preeclampsia, a gestational hypertension disorder affecting blood supply of the placenta. Mice deficient in Prss8 resulted in the death of embryos at embryonic day (E) 14.5 and it was characterized by impaired placental labyrinth maturation and vascularization. A pale phenotype was observed in these embryos, suggesting in...

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Literature Corpus work: 70f7de40-1720-5eb8-9806-ef02886d85ec
DOI: 10.1101/2024.10.25.620248

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