Article
Intersection of regulatory pathways controlling hemostasis and hemochorial placentation.
Proceedings of the National Academy of Sciences of the United States of America - 14 Dec 2021
Muto Masanaga, Chakraborty Damayanti, Varberg Kaela M, Moreno-Irusta Ayelen, Iqbal Khursheed, Scott Regan L, McNally Ross P, Choudhury Ruhul H, Aplin John D, Okae Hiroaki, Arima Takahiro, Matsumoto Shoma, Ema Masatsugu, Mast Alan E, Grundberg Elin, Soares Michael J
Abstract excerpt
Hemochorial placentation is characterized by the development of trophoblast cells specialized to interact with the uterine vascular bed. We utilized trophoblast stem (TS) cell and mutant rat models to investigate regulatory mechanisms controlling trophoblast cell development. TS cell differentiation was characterized by acquisition of transcript signatures indicative of an endothelial cell-like phenotype, which...
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