Back to search

Article

FOSL2 Gene Expression Declines with Age in Bone Marrow-derived MSCs

2024-05-14

Abstract excerpt

The FOSL2 gene, integral to the AP-1 transcription factor complex, orchestrates cellular responses to stimuli, including immune surveillance and tissue-resident memory T cell differentiation. This study investigates FOSL2's expression dynamics across ages to elucidate its role in aging and age-associated diseases. Leveraging gene expression profiles in response to environmental challenges, we hypothesize that FOSL...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
70f35915-7cb1-5dba-8e25-ab8318454bbb
DOI
10.1101/2024.05.11.593704
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
FOSL2 Gene Expression Declines with Age in Bone Marrow-derived MSCsDOI 10.1101/2024.05.11.593704
Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray dataSemantic proximity
A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiationSemantic proximity
Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis.Semantic proximity
The AP-1 factors <i>FOSL1</i> and <i>FOSL2</i> co-regulate human Th17 responsesSemantic proximity
AP-1 complex activation is a conserved signature of immune system aging and a potential regulator of inflammaging in human and miceSemantic proximity
An Inflammatory and Quiescent HSC Subpopulation Expands with Age in HumansSemantic proximity
Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factorsSemantic proximity
LEF1 isoforms regulate cellular senescence and agingSemantic proximity
Enhancer-priming in ageing human bone marrow mesenchymal stromal cells contributes to immune traitsSemantic proximity
Mapping Interactome Networks of FOSL1 and FOSL2 in Human Th17 CellsSemantic proximity
Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammagingSemantic proximity
T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide AnalysisSemantic proximity
Select a neighboring publication to make it the new centre.