Article

Enhancer-priming in ageing human bone marrow mesenchymal stromal cells contributes to immune traits

2021-09-05

Abstract excerpt

Bone marrow mesenchymal stromal cells (BMSCs) can differentiate into adipocytes and osteoblasts, and are important regulators of the haematopoietic system. Ageing associates with an increased ratio of bone marrow adipocytes to osteoblasts and immune dysregulation. Here, we carried out an integrative multiomics analysis of ATAC-Seq, RNA-Seq and proteomics data from primary human BMSCs in a healthy cohort age betwee...

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Literature Corpus work: 374c040f-1255-555a-8881-28b262cbe2b3
DOI: 10.1101/2021.09.03.458728

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