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Plasmodium falciparum subverts neutrophil function via host miR-451a loaded extracellular vesicles driving bacterial superinfection susceptibility

2025-06-04

Abstract excerpt

<h4>Summary</h4> Malaria caused by Plasmodium falciparum ( Pf ) compromise innate immunity, yet the underlying mechanisms remain elusive. The immune dysregulation caused by the parasite may lead to bacterial superinfections and increase mortality. We reveal that Pf exploits extracellular vesicles (EVs) secreted by infected red blood cells (iRBC-EVs) to deliver host-derived miR451a to human neutrophils, impairin...

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Literature Corpus work
70cc6346-8950-5661-a803-bda05071d2e4
DOI
10.1101/2025.06.02.657463
Open publication

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Plasmodium falciparum subverts neutrophil function via host miR-451a loaded extracellular vesicles driving bacterial superinfection susceptibilityDOI 10.1101/2025.06.02.657463
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