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Extracellular vesicles from early stagePlasmodium falciparum-infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes

19 Jan 2018

Abstract excerpt

Pathogens can release extracellular vesicles (EVs) for cell-cell communication and host modulation. EVs from Plasmodium falciparum, the deadliest malaria parasite species, can transfer drug resistance genes between parasites. EVs from late-stage parasite-infected RBC (iRBC-EVs) are immunostimulatory and affect endothelial cell permeability, but little is known about EVs from early stage iRBC. We detected the...

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PMID: 29349926
DOI: 10.1111/cmi.12822

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