Article

Cell-to-cell and genome-to-genome variability of Adenovirus transcription tuned by the cell cycle

2020-02-27

Abstract excerpt

In clonal cultures, not all cells are equally susceptible to virus infection. Underlying mechanisms of infection variability are poorly understood. Here, we developed image-based single cell measurements to scrutinize the heterogeneity of adenovirus (AdV) infection. AdV delivers, transcribes and replicates a linear double-stranded DNA genome in the nucleus. We measured the abundance of viral transcripts by single-...

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Literature Corpus work: 70ca9d6e-4145-5422-8d26-ad04f846b29c
DOI: 10.1101/2020.02.27.967471

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