Temporal Viral Genome-Protein Interactions Define Distinct Stages of Productive Herpesviral Infection

Abstract excerpt

ABSTRACT Herpesviruses utilize multiple mechanisms to redirect host proteins for use in viral processes and to avoid recognition and repression by the host. To investigate dynamic interactions between herpes simplex virus type 1 (HSV-1) DNA and viral and host proteins throughout infection, we developed an approach to identify proteins that associate with the infecting viral genome from nuclear entry through...

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