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HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations

15 May 2019

Abstract excerpt

Viral infection is usually studied at the population level by averaging over millions of cells. However, infection at the single-cell level is highly heterogeneous, with most infected cells giving rise to no or few viral progeny while some cells produce thousands. Analysis of Herpes Simplex virus 1 (HSV-1) infection by population-averaged measurements has taught us a lot about the course of viral infection, but...

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PMID: 31090537
DOI: 10.7554/elife.46339

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