Article

GNAS mutations suppress the cell invasion through regulating EMT by activating the MEG3/Wnt/β-catenin pathway in growth hormone-secreting pituitary adenoma

2022-08-11

Abstract excerpt

<h4>Background: </h4> Approximately 30–40% of growth hormone-secreting pituitary adenoma (GHPA) harbor somatic mutations in the GNAS (α subunit of the stimulatory G protein) gene. However, the latent functional role of the mutations and relative molecular mechanism in GHPA remain unknown. <h4>Methods: </h4>: The GNAS gene mutations were detected in GHPAs using a standard PCR-sequencing procedure. The mutation-asso...

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Literature Corpus work: 70c5ccce-5006-5be1-9823-b1b2a350d3e7
DOI: 10.21203/rs.3.rs-1935777/v1

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