Article

Transcriptomic classification of pituitary neuroendocrine tumors causing acromegaly

2022-07-28

Abstract excerpt

Acromegaly results from growth hormone hypersecretion caused by somatotroph pituitary neuroendocrine tumor (PitNET). Our molecular profiling revealed that acromegaly-causing tumors form three distinct transcriptomic subgroups with different histological/clinical features. Transcriptomic subtypes of somatotroph tumors differ in the expression levels of numerous genes including those involved in hormone secretion an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa76bcc2-4282-508d-9fa4-daeb2b0553c2
DOI: 10.1101/2022.07.26.501638

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic classification of pituitary neuroendocrine tumors causing acromegalyDOI 10.1101/2022.07.26.501638Read

Transcriptomic Classification of Pituitary Neuroendocrine Tumors Causing AcromegalySemantic proximity Read

Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumorsSemantic proximity Read

Transcriptomic perspective on acromegaly- related PIT-1/SF-1 positive pituitary tumorsSemantic proximity Read

Proteogenomic Landscape and Clinical Characterization of GH-Producing Pituitary AdenomaSemantic proximity Read

Co-secretion of growth hormone and prolactin defines a high-risk acromegaly phenotypeSemantic proximity Read

Transcriptomic Profiles of Normal Pituitary Cells and Pituitary Neuroendocrine Tumor CellsSemantic proximity Read

Single-cell transcriptome and genome analyses of pituitary neuroendocrine tumorsSemantic proximity Read

Pangenomic Classification of Pituitary Neuroendocrine Tumors.Semantic proximity Read

Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumorsSemantic proximity Read

Transcription Factor–Based Classification of Pituitary Neuroendocrine Tumors: Practical Immunohistochemical Algorithms, Molecular Correlates, and Diagnostic Challenges in the 5th WHO EraSemantic proximity Read

Annotation of pituitary neuroendocrine tumors with genome-wide expression analysisSemantic proximity Read

Co-secretion of growth hormone and prolactin defines a high-risk acromegaly phenotype.Semantic proximity Read