Mutations in the GNAS Gene Prevent the Cell Invasion by Activating the MEG3/Wnt/β-catenin Axia in Growth Hormone-secreting Pituitary Adenoma

Abstract excerpt

Approximately 30–40% of growth hormone-secreting pituitary adenoma (GHPA) harbor somatic mutations in the GNAS (α subunit of the stimulatory G protein) gene. However, the latent functional role of the mutations and relative molecular mechanism in GHPA remain unknown. The GNAS gene mutations were detected in GHPAs using a standard PCR-sequencing procedure. The mutation-associated MEG3 expression was measured by RT-...

Topics

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• Chromogranins
• Epithelial-Mesenchymal Transition
• Gene Expression Regulation, Neoplastic
• GTP-Binding Protein alpha Subunits, Gs
• Neoplasm Invasiveness
• RNA, Long Noncoding
• Wnt Signaling Pathway
• Xenograft Model Antitumor Assays

Identifiers and source

Literature Corpus work

6d15a047-e121-513e-adbc-56e63712f8cb

DOI

10.21203/rs.3.rs-1173994/v2