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Article

Multi-transcriptomics analysis identifies NNAT as a key molecule driving the invasive phenotype across all lineages of pituitary adenomas.

Neuro-oncology - 1 Aug 2026

Liu Meng, Wang Hongyi, Guo Jing, Li Xuejing, Liu Changxiaofeng, Wang Jialin, Yi Zhaoyi, Xue Wenbin, Fang Qiuyue, Wang Hongyun, Gong Lei, Zhang Yazhuo, Li Chuzhong, Xie Weiyan

Abstract excerpt

BACKGROUND: Although histologically benign, invasive pituitary adenomas exhibit malignant-like biological behavior, characterized by local invasiveness and high proliferative activity. Clinical management remains challenging due to the absence of effective targeted therapies, difficulties with surgical resection, and high risks of postoperative residual disease and recurrence. Precise therapeutic targets are...

Topics

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Adenoma
Biomarkers, Tumor
Cell Proliferation
Gene Expression Regulation, Neoplastic
Neoplasm Invasiveness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pituitary Neoplasms

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 42166756
DOI: 10.1093/neuonc/noag113
PMCID: PMC13437893

Genes

NNAT
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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