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Article

GNAS Mutations: Drivers or Co-Pilots? Yet, Promising Diagnostic Biomarkers.

Trends in cancer - 1 Jun 2016

Innamorati Giulio, Valenti Maria Teresa, Giacomello Luca, Dalle Carbonare Luca, Bassi Claudio

Abstract excerpt

Over 25 years ago, GNAS mutations were discovered associated with McCune-Albright syndrome (MAS) and pituitary tumors. The mutant gene, encoding the heterotrimeric Gs protein, was named 'derived from Gs Protein' (gsp) oncogene. For a long time, gsp remained associated with specific endocrine tumors. Recently, high frequencies of gsp were reported for a rapidly growing number of neoplasms in the gastrointestinal...

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Identifiers

PMID: 28741526
DOI: 10.1016/j.trecan.2016.05.005

Genes

GNAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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