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Article

GNAS mutations suppress cell invasion by activating MEG3 in growth hormone-secreting pituitary adenoma.

Oncology research - 1 Jan 2024

Tang Chao, Zhong Chunyu, Zhu Junhao, Yuan Feng, Yang Jin, Xu Yong, Ma Chiyuan

Abstract excerpt

Approximately 30%-40% of growth hormone-secreting pituitary adenomas (GHPAs) harbor somatic activating mutations in GNAS (α subunit of stimulatory G protein). Mutations in GNAS are associated with clinical features of smaller and less invasive tumors. However, the role of GNAS mutations in the invasiveness of GHPAs is unclear. GNAS mutations were detected in GHPAs using a standard polymerase chain reaction (PCR)...

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Share to Chromogranins
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Neoplasm Invasiveness

Share to RNA, Long Noncoding

Share to Wnt Signaling Pathway

Share to Xenograft Model Antitumor Assays

Source

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Identifiers

PMID: 38827318
DOI: 10.32604/or.2024.046007
PMCID: PMC11136687

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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