Article

Nutritional deficiency recapitulates intestinal injury associated with environmental enteric dysfunction in patient-derived Organ Chips

2021-10-14

Abstract excerpt

<h4>ABSTRACT</h4> Environmental Enteric Dysfunction (EED) is a chronic inflammatory condition of the intestine characterized by villus blunting, compromised intestinal barrier function, and reduced nutrient absorption. Here, we show that key genotypic and phenotypic features of EED-associated intestinal injury can be reconstituted in a human intestine-on-a-chip (Intestine Chip) microfluidic culture device lined by...

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Literature Corpus work: 709d89f1-ef7a-530b-86ce-408d9cfb5067
DOI: 10.1101/2021.10.11.21264722

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